This comprehensive Python Programming textbook, designed for University of Mumbai's First Year Engineering students (Semester II), covers essential programming concepts across all branches under course code VSEC102. Following the NEP-2020 scheme for Academic Year 2024-25, this practical-focused guide systematically explores Python fundamentals through six well-structured modules. Starting with Python basics, it progresses through control flow, functions, file operations, and debugging techniques. The book delves into Object-Oriented Programming principles and concludes with advanced Python concepts and library implementations. Perfect for both classroom learning and self-study, this textbook combines theoretical knowledge with hands-on practical exercises. The content is thoughtfully curated by experienced academicians from prestigious institutions, ensuring students gain thorough understanding of Python programming fundamentals. Whether you're a beginner or looking to strengthen your programming foundation, this book serves as an invaluable resource for mastering Python programming concepts.