The book, “Amphibian Experiments in Physiology: All you need to know,” serves as a pathway from the “known to unknown”. As aspiring doctors embarking on the journey of MBBS, you often find yourselves engulfed in a sea of abstract concepts that are challenging to grasp visually. Among these challenges lies the realm of amphibian experiments, a domain that once played a significant role in medical education but has now been largely replaced by simulations due to regulatory changes. However, while simulations offer solutions, they may not fully address conceptual uncertainties. Teachers strive to convey understanding of experiments that you may not have witnessed firsthand. In this book, we provide hand-drawn illustrations and graphs to represent these experiments, alongside original figures wherever feasible, aiming to bridge the gap between theory and practice.